Police said a Ford Festiva veered off the Great Western Highway at Yetholme about 10.20pm, hitting a tree.

Emergency services were called and found the front passenger, an 18-year-old woman, died at the scene.

The male driver suffered serious injuries and was taken to Orange Hospital.

A female passenger in the back seat of the vehicle suffered multiple fractures and was taken to Liverpool Hospital, where she remains in a stable condition.

A second passenger in the back of the car, a 21-year-old man, was airlifted to Liverpool Hospital, where he remains in a critical condition.

Officers attached to Chifley Local Area Command and Crash Investigation Unit attended and are investigating the incident.

A report will be prepared for the coroner. No further information is available at this time.

Police are urging anyone with information in relation to this incident to call Crime Stoppers on 1800 333 000 or use the Crime Stoppers online reporting page nsw.crimestoppers.com.au/

Information will be treated in the strictest of confidence.