Two people have been flown to Orange Base Hospital in a serious but stable condition after two cars collided head-on between Gooloogong and Canowindra around midday.
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A 52-year-old woman and a 68-year-old man were driving in opposite directions on Warraderry Road at around 11.40am when their front right wheels collided on a bend, forcing one driver off the road.
Both drivers were trapped in their vehicles for over an hour while paramedics, police and NSW Fire and Rescue worked to free them.
The road was closed in both directions with traffic banked up heading towards Gooloogong.
Helicopters were on standby while officers attempted to release the victims from their vehicles.
Central West Ambulance Duty Operations Manager, Inspector Peter Rowlands said because the collision was wheel to wheel, it was very difficult circumstances for retrieval crews.
He said the man sustained abdominal and lower leg injuries while the woman received lower leg injuries.
Inspector Dave Harvey said both victims were the sole occupants of their vehicles at the time and were from the local area.
The incident is currently being investigated by police.